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Tiistaimeeting 15.02.2005 - Renal pathology
Heikki Helin
Division of Pathology, HUSLAB,
University Central Hospital,
Helsinki, Finland
 
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Case 1 - male, 40 years
Previously healthy nonsmoker. Occupational exposure to chalk dust. For one month fever, arthralgia and hemoptysis. BAL and chest x-ray suggest alveolar hemorrhage. Serum ANCA-antibodies negative. Serum creatinine 93 mmol/l, hematuria of 20 RBC/microscopic field.

Slide 1 = PAS
Slide 2 = PASM
Slide 3 = Immunofluorescence microscopy of the renal biopsy specimen, staining anti-IgG-FITC (snapshot only)
  

 Diagnosis & discussion

 
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Case 2 - female, 14 years
Submitted to hospital for hypertensive crisis. No radiological signs of fibromuscular dysplasia. Renal blood flow impaired. No evidence of vasculitis.

Slide 1 = PAS
  

 Diagnosis & discussion

 
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Slide 2  
Case 3 - female, 6 years
Renal transplantation for cystinosis and uremia. Biopsy 4 weeks post transplantation because of nonfunctioning transplant.

Slide 1 = H&E staining
Slide 2 = Masson
  

 Diagnosis & discussion

 
Slide 1  
Slide 2  
Case 4 - female, 6 years
Renal transplantation for nephronophtisis four months before renal biopsy. Acute rejection three months post transplantation, treated with methyl prednison. Control renal biopsy after treatment.

Slide 1 = H&E staining
Slide 2 = PAS
  

 Diagnosis & discussion

 
Slide 1  
Slide 2  
Slide 3  
Case 5a - male, 44 years
Cadaver renal transplantation for membranoproliferative glomerulonephritis, normal function initially. Severe pneumonia and sepsis four days after transplantation. Renal biopsy 24 days post transplantation for impaired function.

Slide 1 = H&E staining
Slide 2 = Masson




Case 5b - male, 44 years
Follow-up biopsy of case 5a after treatment

Slide 3 = Masson.
  

 Diagnosis & discussion

 
Slide 1  
Slide 2  
Slide 3  
Case 6 - male, 52 years
Cadaver renal transplantation after Goodpasture´s syndrome. Non-functioning kidney biopsied two weeks post transplantation.

Slide 1 = HE
Slide 2 = Masson
Slide 3 = Immunoperoxidase staining for the complement component C4d (snapshot only)


  

 Diagnosis & discussion

 
Slide 1  
Slide 2  
Case 7 - male, 65 years
Renal transplantation 9 years ago because of polycystic kidney disease. Clinical examinations performed for anemia and hypersedimentation disclosed IgG-kappa type paraprotein and proteinuria of 8 g/d.

Slide 1 = PAS
Slide 2 = PASM
  

 Diagnosis & discussion

 
Slide 1  
Slide 2  
Case 8 - male, 12 years
Renal transplantation 18 months ago for polycystic kidney disease. Decreased GFR, serum creatinine 129 mmol/l, u-prot excretion 75 mg/d.

Slide 1 = PAS
Slide 2 = PASM


  

 Diagnosis & discussion


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